First Author | van Ree JH | Year | 1997 |
Journal | Genomics | Volume | 39 |
Issue | 3 | Pages | 393-5 |
PubMed ID | 9119377 | Mgi Jnum | J:38416 |
Mgi Id | MGI:85786 | Doi | 10.1006/geno.1996.4472 |
Citation | van Ree JH, et al. (1997) The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13. Genomics 39(3):393-5 |
abstractText | Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the beta-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12-p13.13, using fluorescence in situ hybridization. |