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Publication : The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11.

First Author  Mock BA Year  1994
Journal  Eur J Immunogenet Volume  21
Issue  4 Pages  231-8
PubMed ID  9098436 Mgi Jnum  J:20027
Mgi Id  MGI:68143 Doi  10.1111/j.1744-313x.1994.tb00196.x
Citation  Mock BA, et al. (1994) The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Eur J Immunogenet 21(4):231-8
abstractText  Nitric oxide synthase has been shown to mediate streptozocin-induced diabetes and to act as an antimicrobial agent in murine macrophages. Using a cDNA probe for the inducible form of nitric oxide synthase (Nos2) isolated from murine macrophages we have determined that the gene maps within 1 cM of the nude mutation on mouse Chromosome 11. The position of Nos2 was also mapped relative to the markers 115, Evi2, Cchlbl (previously unmapped), and Gfap. This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis (ScII) and autoimmune type-I diabetes (Idd4).
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