| First Author | Lindahl KF | Year | 1997 |
| Journal | Annu Rev Immunol | Volume | 15 |
| Pages | 851-79 | PubMed ID | 9143709 |
| Mgi Jnum | J:40178 | Mgi Id | MGI:87522 |
| Doi | 10.1146/annurev.immunol.15.1.851 | Citation | Lindahl KF, et al. (1997) H2-M3, a full-service class Ib histocompatibility antigen. Annu Rev Immunol 15:851-79 |
| abstractText | H2-M3 is an MHC class Ib molecule of the mouse with a unique preference for N-formylated peptides, which may come from the N-termini of endogenous, mitochondrial proteins or foreign, bacterial proteins. The crystal structure of M3 revealed a hydrophobic peptide-binding groove with an occluded A pocket and the peptide shifted one residue relative to class Ia structures. The formyl group is held by a novel hydrogen bonding network, involving His9 on the bottom of the groove, and the side chain of the P1 methionine is lodged in the B pocket. M3 is a full-service histocompatibility (H) antigen, i.e. self-M3 can present endogenous peptides as minor H antigens and foreign, bacterial antigens in a defensive immune response to infection; and foreign M3 complexed with endogenous self-peptides. |
