| First Author | Ozkaynak E | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 234 |
| Issue | 1 | Pages | 242-6 |
| PubMed ID | 9168996 | Mgi Jnum | J:40349 |
| Mgi Id | MGI:87689 | Doi | 10.1006/bbrc.1997.6624 |
| Citation | Ozkaynak E, et al. (1997) Osteogenic protein-1 mRNA in the uterine endometrium. Biochem Biophys Res Commun 234(1):242-6 |
| abstractText | OP-1, a bone morphogenetic protein (BMP) in the TGF-beta superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of non-pregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in the trophoblastic giant cells of the placenta and the fetal tissues. The uterine OP-1 mRNA downregulation could be mimicked by administration of 17 beta-estradiol but not by progesterone to non-pregnant animals. In contrast, OP-1 mRNA expression in kidneys and ovaries was not affected by pregnancy or estrogen treatment. The selective effect of estrogen on OP-1 mRNA in the uterus suggests that OP-1 expression is regulated by tissue specific mechanisms. |
