| First Author | Lutz CM | Year | 1997 |
| Journal | Genomics | Volume | 41 |
| Issue | 3 | Pages | 498-500 |
| PubMed ID | 9169155 | Mgi Jnum | J:40158 |
| Mgi Id | MGI:87502 | Doi | 10.1006/geno.1997.4698 |
| Citation | Lutz CM, et al. (1997) Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. (Erratum: v. 44(2):251). Genomics 41(3):498-500 |
| abstractText | Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31-q32. We have now assigned Npy1r and Npy2r to conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein- coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity. (C) 1997 Academic Press. |
