| First Author | Kapelle M | Year | 1997 |
| Journal | Biochim Biophys Acta | Volume | 1352 |
| Issue | 1 | Pages | 13-7 |
| PubMed ID | 9177477 | Mgi Jnum | J:40213 |
| Mgi Id | MGI:87555 | Doi | 10.1016/s0167-4781(97)00043-2 |
| Citation | Kapelle M, et al. (1997) cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF). Biochim Biophys Acta 1352(1):13-7 |
| abstractText | Germ cell nuclear factor (GCNF) was initially described in the mouse as a germ cell-specific orphan member of the nuclear receptor superfamily. Two full-length cDNAs encoding variants of the human germ cell nuclear factor (GCNF) differing by only one amino acid residue have now been isolated from a human testis cDNA library and characterised. The encoded proteins show 98.3% and 82.7% amino acid identity with mouse and Xenopus GCNF, respectively. Northern blot hybridisation revealed the expression of an 8 kb human GCNF mRNA exclusively in the testis. The alignment of the GCNF protein sequence with other members of the nuclear hormone receptor family suggests an unusual structural organisation of the C-terminal portion of the putative ligand-binding domain. |
