| First Author | Gaufo GO | Year | 1997 |
| Journal | Brain Res | Volume | 756 |
| Issue | 1-2 | Pages | 191-9 |
| PubMed ID | 9187332 | Mgi Jnum | J:40468 |
| Mgi Id | MGI:87813 | Doi | 10.1016/s0006-8993(97)00149-2 |
| Citation | Gaufo GO, et al. (1997) Thymus graft reverses morphological deficits in dorsolateral frontal cortex of congenitally athymic nude mice. Brain Res 756(1-2):191-9 |
| abstractText | The present investigation offers a basis for demonstrating that the cerebral cortex can be directly accessed through the immune system. This project was undertaken to provide a necessary step in confirming that the localized, deficient area of the cerebral cortex in the congenitally athymic nude mouse is related to the thymus, a gland necessary for the development of T-cells and the regulation of the neuro-endocrine system. We report that thymus engraftment, confirmed by reconstitution of CD4 and CD8 T-cells, in 30-day-old congenitally athymic female mice reverses deficiencies in the frontal cortex by day 60. A concomitant increase in serum prolactin was observed in thymic-grafted nude mice, suggesting a role by which prolactin may produce the morphological changes observed in the cerebral cortex. |
