| First Author | Mitsuyoshi S | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 235 |
| Issue | 1 | Pages | 191-6 |
| PubMed ID | 9196061 | Mgi Jnum | J:41025 |
| Mgi Id | MGI:892751 | Doi | 10.1006/bbrc.1997.6759 |
| Citation | Mitsuyoshi S, et al. (1997) Expression of the proliferation-related Ki-67 mRNA in the early development of murine embryo. Biochem Biophys Res Commun 235(1):191-6 |
| abstractText | In a search for early lymphoid-specific genes, we isolated a cDNA clone (LL7) encoding a murine homologue of Ki-67 protein, a proliferation-related nuclear antigen. LL7 transcript appears preferentially in lymphoid organs as the bone marrow, spleen, and the thymus. Here, we studied the expression of murine Ki-67 (mKi-67) mRNA among various organs or tissues during the early development of fetus. In fetus, mKi-67 mRNA appears developmentally as early as day 11 and is expressed maximally at day 15. In situ hybridization on the section revealed that the expression of mKi-67 mRNA is preferential in the area of active organ formation such as neurological system and the fetal liver. These results suggest that mKi-67 plays an important role in the proliferation of early embryonic precursor cells of neurological and immune systems. |
