| First Author | Renedo M | Year | 1997 |
| Journal | Immunogenetics | Volume | 46 |
| Issue | 4 | Pages | 307-11 |
| PubMed ID | 9218532 | Mgi Jnum | J:42538 |
| Mgi Id | MGI:1095962 | Doi | 10.1007/s002510050276 |
| Citation | Renedo M, et al. (1997) The human natural killer gene complex is located on chromosome 12p12-p13. Immunogenetics 46(4):307-11 |
| abstractText | Natural killer (NK) cells preferentially express several type II glycoproteins of the calcium-dependent lectin superfamily. The genes coding for these molecules are clustered on the distal mouse chromosome 6 and on the rat chromosome 4 in a region designated the NK gene complex. To date, no definite evidence of the presence of a NK gene complex has been found in humans. Here we report the assignment by fluorescence in situ hybridization of the CD94 gene to human chromosome 12p12-p13, in the same region where the CD69 and NKG2A genes had been previously mapped. In addition, using a yeast artificial chromosome contig spanning this region we determined that the human CD94, NKG2A, NKG2C, NKGZE, and NKR-P1A (NKR) genes map to the short arm of chromosome 12. The distal to proximal position of these loci are: NKR-CD69 - CD94/NKG2A/NKG2C/NKG2E. These data demonstrate the existence of a human NK gene complex located within a 5.6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases. |
