| First Author | Cairns LA | Year | 1997 |
| Journal | Oncogene | Volume | 14 |
| Issue | 25 | Pages | 3093-8 |
| PubMed ID | 9223673 | Mgi Jnum | J:41585 |
| Mgi Id | MGI:894072 | Doi | 10.1038/sj.onc.1201137 |
| Citation | Cairns LA, et al. (1997) Immortalization of neuro-endocrine cells from adrenal tumors arising in SV40 T-transgenic mice. Oncogene 14(25):3093-8 |
| abstractText | Pheochromocytomas are adrenal medullary tumors which arise from the transformation of neural crest-derived cells. In the course of studies of mice transgenic for an SV40 T-gene ectopically expressed in the adrenal medulla, we observed the occurrence of large, mainly bilateral tumors in a high proportion of transgenic animals. From these tumors we established immortalized cell lines which grow in vitro at 32 degrees C (the permissive temperature for the tsA58 T-protein encoded by the transgene), but not at 38 C. These cells demonstrate characteristics of both neuronal (160 kd neurofilament) and endocrine (chromogranins) cells. The expression of Mash-1 and ret supports their initial characterization as early bipotential neuro-endocrine progenitors. |
