| First Author | Alevizopoulos A | Year | 1997 |
| Journal | Bioessays | Volume | 19 |
| Issue | 7 | Pages | 581-91 |
| PubMed ID | 9230691 | Mgi Jnum | J:41708 |
| Mgi Id | MGI:894238 | Doi | 10.1002/bies.950190709 |
| Citation | Alevizopoulos A, et al. (1997) Transforming growth factor-beta: the breaking open of a black box. Bioessays 19(7):581-91 |
| abstractText | Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases. |
