| First Author | Alroy I | Year | 1997 |
| Journal | FEBS Lett | Volume | 410 |
| Issue | 1 | Pages | 83-6 |
| PubMed ID | 9247128 | Mgi Jnum | J:42224 |
| Mgi Id | MGI:1095362 | Doi | 10.1016/s0014-5793(97)00412-2 |
| Citation | Alroy I, et al. (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410(1):83-6 |
| abstractText | Ligand-induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo- and heterodimeric receptor complexes. Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting a different set of Src homology 2- (SH2-) containing effector proteins. Further complexity is added due to the existence of an oncogenic receptor that enhances and stabilizes dimerization but has no ligand (ErbB-2), and a receptor that can recruit novel SH-2-containing proteins, but is itself devoid of kinase activity (ErbB-3). The resulting signaling network has important implications for embryonic development and malignant transformation. |
