| First Author | Darnell JE Jr | Year | 1997 |
| Journal | Science | Volume | 277 |
| Issue | 5332 | Pages | 1630-5 |
| PubMed ID | 9287210 | Mgi Jnum | J:42874 |
| Mgi Id | MGI:1096694 | Doi | 10.1126/science.277.5332.1630 |
| Citation | Darnell JE Jr (1997) STATs and gene regulation. Science 277(5332):1630-5 |
| abstractText | STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins. |
