| First Author | Kang JA | Year | 1997 |
| Journal | Am J Reprod Immunol | Volume | 38 |
| Issue | 3 | Pages | 183-8 |
| PubMed ID | 9325490 | Mgi Jnum | J:44777 |
| Mgi Id | MGI:1101291 | Doi | 10.1111/j.1600-0897.1997.tb00296.x |
| Citation | Kang JA, et al. (1997) Expression of TJ6 during pregnancy. Am J Reprod Immunol 38(3):183-8 |
| abstractText | PROBLEM: TJ6 will be one of the molecules involved in fetal-specific immune suppression during pregnancy. In the mouse and human decidua, the regulation of uterine natural killer (uNK) cells is important during pregnancy. METHOD OF STUDY: To further understand the possible functions of TJ6 during pregnancy, syngeneic, allogeneic, and mutant mice were examined for TJ6 expression. RESULTS: Immunoblotting showed that TJ6 protein was expressed on most of the placenta-associated mononuclear cells, and the size was 70-72 kDa at all stages of pregnancy. The expression of TJ6 mRNA was studied by a ribonuclease protection assay in syngeneic and allogeneic matings, and in immune-deficient mice of genotypes scid/scid and scid/scid.bg/bg. CONCLUSIONS: Genetic disparity, lack of T and B lymphocytes, and loss of NK lytic function had no significant effect on the expression of TJ6 mRNA. |
