| First Author | Sheardown SA | Year | 1997 |
| Journal | Cell | Volume | 91 |
| Issue | 1 | Pages | 99-107 |
| PubMed ID | 9335338 | Mgi Jnum | J:43430 |
| Mgi Id | MGI:1097725 | Doi | 10.1016/s0092-8674(01)80012-x |
| Citation | Sheardown SA, et al. (1997) Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Cell 91(1):99-107 |
| abstractText | The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation. Unstable transcript is produced by both alleles in XX ES cells and in XX embryos prior to the onset of random X inactivation. Following differentiation, transcription of unstable RNA from the active X chromosome allele continues for a period following stabilization and accumulation of transcript on the inactive X allele. We discuss the implications of these findings in terms of models for the initiation of random and imprinted X inactivation. |
