| First Author | Bartek J | Year | 1997 |
| Journal | Exp Cell Res | Volume | 237 |
| Issue | 1 | Pages | 1-6 |
| PubMed ID | 9417859 | Mgi Jnum | J:44753 |
| Mgi Id | MGI:1101267 | Doi | 10.1006/excr.1997.3776 |
| Citation | Bartek J, et al. (1997) The retinoblastoma protein pathway in cell cycle control and cancer. Exp Cell Res 237(1):1-6 |
| abstractText | Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the RB pathway whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine. |
