| First Author | Vullhorst D | Year | 1998 |
| Journal | FEBS Lett | Volume | 421 |
| Issue | 3 | Pages | 259-62 |
| PubMed ID | 9468318 | Mgi Jnum | J:45544 |
| Mgi Id | MGI:1195594 | Doi | 10.1016/s0014-5793(97)01577-9 |
| Citation | Vullhorst D, et al. (1998) Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. FEBS Lett 421(3):259-62 |
| abstractText | We report the detailed expression pattern of the voltage-dependent potassium channel KV3.4 (rat homologue, Raw3) in mouse skeletal muscle. Using semi-quantitative RT-PCR, we show that its expression is detectable at embryonic day 17 and rises to adult levels within 2 weeks after birth. Expression is fiber type-dependent, with mRNA levels being 5-6-fold lower in the mixed slow/fast soleus muscle than in the fast tibialis anterior and extensor digitorum longus muscles. Fast muscles from myotonic mice exhibit low KV3.4 mRNA levels similar to those of wild-type soleus. In denervated extensor digitorum longus, KV3.4 expression declines to perinatal levels. We conclude that KV3.4 expression in mouse skeletal muscle is regulated by the pattern of excitation. |
