| First Author | Schito AM | Year | 1997 |
| Journal | Neurosci Lett | Volume | 239 |
| Issue | 1 | Pages | 49-53 |
| PubMed ID | 9547169 | Mgi Jnum | J:45856 |
| Mgi Id | MGI:1196196 | Doi | 10.1016/s0304-3940(97)00853-7 |
| Citation | Schito AM, et al. (1997) mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit. Neurosci Lett 239(1):49-53 |
| abstractText | The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups. |
