| First Author | Joyce S | Year | 1998 |
| Journal | Science | Volume | 279 |
| Issue | 5356 | Pages | 1541-4 |
| PubMed ID | 9488653 | Mgi Jnum | J:46434 |
| Mgi Id | MGI:1197851 | Doi | 10.1126/science.279.5356.1541 |
| Citation | Joyce S, et al. (1998) Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science 279(5356):1541-4 |
| abstractText | Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK1+ natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as a major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells. |
