| First Author | Hughes DC | Year | 1998 |
| Journal | Genomics | Volume | 48 |
| Issue | 1 | Pages | 46-51 |
| PubMed ID | 9503015 | Mgi Jnum | J:43211 |
| Mgi Id | MGI:1097311 | Doi | 10.1006/geno.1997.5159 |
| Citation | Hughes DC, et al. (1998) Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness. Genomics 48(1):46-51 |
| abstractText | alpha-Tectorin is one of the major major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped thc gene encoding alpha-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing alpha-tectorin have bees identified, demonstrating physical linkage to the anonymous marker D11S925. This places alpha-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome, Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA. (C) 1998 Academic Press. |
