First Author | Blair HJ | Year | 1998 |
Journal | Genomics | Volume | 48 |
Issue | 1 | Pages | 128-31 |
PubMed ID | 9503026 | Mgi Jnum | J:46280 |
Mgi Id | MGI:1197447 | Doi | 10.1006/geno.1997.5144 |
Citation | Blair HJ, et al. (1998) An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome. Genomics 48(1):128-31 |
abstractText | The genes for ocular albinisim type 1 (OA1) and the Xenopus laevis-like apical protein (APXL) map between amelogenin (AMELX) and the pseudoautosomal boundary in the distal region of the human X chromosome short arm. The mouse homologues, Oa1 and Apxl, have recently been shown to lie proximal to their expected locations on the mouse X chromosome, but their positions with respect to critical gene loci in the vicinity have not been defined. By analyzing recombination events from (Mus musculus x Mus spretus) x M. musculus backcrosses, we have constructed a detailed mouse genetic map that encompasses Oa1, five other genes, and 13 microsatellite loci. The order of genes and evolutionary breakpoints (EB) is defined as centromere-(EB)-(DXHXS674, DXHXS679)- Smcx-(EB)-Oa1-(EB)-Phex (3'-->5')-Pdha1-telomere. Thus Oa1 lies in a region between two previously characterized conserved segments. |