| First Author | Mori C | Year | 1998 |
| Journal | Mol Reprod Dev | Volume | 49 |
| Issue | 4 | Pages | 374-85 |
| PubMed ID | 9508088 | Mgi Jnum | J:46115 |
| Mgi Id | MGI:1197150 | Doi | 10.1002/(SICI)1098-2795(199804)49:4<374::AID-MRD4>3.0.CO;2-K |
| Citation | Mori C, et al. (1998) Mouse spermatogenic cell-specific type 1 hexokinase (mHk1-s) transcripts are expressed by alternative splicing from the mHk1 gene and the HK1-S protein is localized mainly in the sperm tail. Mol Reprod Dev 49(4):374-85 |
| abstractText | Unique type 1 hexokinase (HK1) mRNAs are present in mouse spermatogenic cells (mHk1-s). They encode a spermatogenic cell-specific sequence region (SSR) but not the porin-binding domain (PBD) necessary for HK1 binding to porin on the outer mitochondrial membrane. This study determined the origin of the multiple Hk1-s transcripts in mouse spermatogenic cells and verified that they are translated in mouse spermatogenic cells. It also showed that a single mHk1 gene encodes the mHk1 transcripts of somatic cells and the mHk1-sa and mHk1-sb transcripts of spermatogenic cells, that alternative exons are used during mHk1 gene expression in mouse spermatogenic cells, and that mHK1-S is translated in mouse spermatogenic cells and is localized mainly with the fibrous sheath in the tail region, not with the mitochondria in the midpiece of mouse sperm. |
