| First Author | Kim I | Year | 1998 |
| Journal | Comp Biochem Physiol B Biochem Mol Biol | Volume | 119 |
| Issue | 1 | Pages | 157-61 |
| PubMed ID | 9530817 | Mgi Jnum | J:46688 |
| Mgi Id | MGI:1201837 | Doi | 10.1016/s0305-0491(97)00299-x |
| Citation | Kim I, et al. (1998) Identification of alternatively spliced Na(+)-Ca2+ exchanger isoforms expressed in the heart. Comp Biochem Physiol B Biochem Mol Biol 119(1):157-61 |
| abstractText | Alternatively spliced isoforms of Na(+)-Ca2+ exchanger were found from various tissues and species. RT-PCR amplification was performed on the basis of our cloned mouse cardiac Na(+)-Ca2+ exchanger and four alternatively spliced isoforms of Na(+)-Ca2+ exchanger were identified. Three (NCX1.3, NCX1.4, and NCX1.12) of them were first identified in the heart, and one isoform (NCX1.12) was a novel spliced variant. These four spliced variants were present in the embryonic and adult atria and ventricles. Different cell types of the heart expressed different spliced isoforms of Na(+)-Ca2+ exchanger. Southern blot analysis indicated that the Na(+)-Ca2+ exchanger gene existed as a single copy in the mouse genome. Thus, the Na(+)-Ca2+ exchanger isoforms expressed in mouse heart are consistent with being produced by alternative splicing and they may have different functions in various cell types in the mouse heart. |
