| First Author | Terling C | Year | 1998 |
| Journal | Eur J Oral Sci | Volume | 106 Suppl 1 |
| Pages | 137-42 | PubMed ID | 9541216 |
| Mgi Jnum | J:46756 | Mgi Id | MGI:1202034 |
| Doi | 10.1111/j.1600-0722.1998.tb02166.x | Citation | Terling C, et al. (1998) Dynamic expression of E-cadherin in ameloblasts and cementoblasts in mice. Eur J Oral Sci 106 Suppl 1:137-42 |
| abstractText | During embryonic development, E-cadherin mediates intercellular adhesion in a variety of epithelia in a spatio-temporal pattern. We have analyzed the distribution of this cell adhesion molecule in the mouse during odontogenesis, at both mRNA and protein levels, in the mandibular first molars and incisors. E-cadherin was strongly expressed at the bell stage by the cells of the dental organ, and by the pre-secretory ameloblasts and the cells of stratum intermedium at the early mineralization stage. At the onset of enamel secretion, E-cadherin disappeared from the apical pool of the ameloblasts and was later absent from the post-secretory ameloblasts. E-cadherin was also found in Hertwig's root sheath and later in the cells producing acellular cementum. These findings indicate that E-cadherin may be involved in the polarization of the ameloblasts and in the early stages of cementogenesis. |
