| First Author | Salomon B | Year | 1998 |
| Journal | J Immunol | Volume | 160 |
| Issue | 2 | Pages | 708-17 |
| PubMed ID | 9551906 | Mgi Jnum | J:45174 |
| Mgi Id | MGI:1194507 | Doi | 10.4049/jimmunol.160.2.708 |
| Citation | Salomon B, et al. (1998) Three populations of mouse lymph node dendritic cells with different origins and dynamics. J Immunol 160(2):708-17 |
| abstractText | We have identified three distinct populations of mouse lymph node dendritic cells (DC) that differ in their capacity to uptake Ag delivered by different routes, and in their dynamics. The I-DCs are large cells that resemble the interdigitating cells and have a mature phenotype and a slow turnover. They derive from the regional tissues. The sm-DCs and sI-DCs are smaller (hence s-DC), have a more immature phenotype and a rapid turnover. The sI-DC phenotype, including CD8alpha expression suggests a lymphoid-related origin. The sI-DC population is expanded 100-fold after an in vivo flt3 ligand treatment. The sm-DC phenotype suggests a myeloid-related origin. Interestingly, sm-DCs can acquire i.v. injected macromolecules in less than 30 min after injection. They may, therefore, play an important role in the immune response against blood Ags. |
