| First Author | Radcliffe RA | Year | 1998 |
| Journal | Behav Genet | Volume | 28 |
| Issue | 1 | Pages | 49-55 |
| PubMed ID | 9573646 | Mgi Jnum | J:46920 |
| Mgi Id | MGI:1202235 | Doi | 10.1023/a:1021408815540 |
| Citation | Radcliffe RA, et al. (1998) Discovery of a new Pomc1 allele in the LS x SS recombinant inbred strains: relationship to locomotor behavior. Behav Genet 28(1):49-55 |
| abstractText | Various lines of evidence suggest that a polymorphism in the gene for proopiomelanocortin, Pomc1, might account for some portion of the genetic variance for open-field activity in the LS x SS RI strains. To test this hypothesis, approximately 1600 bp of Pomc1 was sequenced from genomic DNA of seven of the LS x SS strains. Two distinct alleles containing a total of five single-base pair differences were detected, A substitution was found in the coding region causing a Pro-to-Ser conversion, two substitutions occurred in the 3' untranslated region of the mRNA, and a substitution and a deletion were detected in the 3' untranscribed flanking region. The fragment containing the coding region substitution was sequenced in an additional 15 of the LS x SS strains. A total of 12 strains contained one form of the allele, while 10 had the other. The strain distribution pattern of open-field activity scores between the two alleles suggests that these alleles do not contribute to the genetic variation of open-field activity in the LS x SS RI strains. |
