| First Author | Pankratova EV | Year | 1998 |
| Journal | FEBS Lett | Volume | 426 |
| Issue | 1 | Pages | 81-5 |
| PubMed ID | 9598983 | Mgi Jnum | J:47146 |
| Mgi Id | MGI:1202664 | Doi | 10.1016/s0014-5793(98)00316-0 |
| Citation | Pankratova EV, et al. (1998) Oct-1 promoter region contains octamer sites and TAAT motifs recognized by Oct proteins [published erratum appears in FEBS Lett 1998 Aug 21;433(3):335]. FEBS Lett 426(1):81-5 |
| abstractText | The 5'-upstream region (1.3 kb) of the gene encoding the POU domain transcription factor Oct-1 was cloned and sequenced. CAT reporter gene analysis of this region has detected a functionally active promoter. This region contains 24 TAAT-core sites, arranged in five clusters (four to six sites in one cluster); two octamer sites (ATGCAAAT) are located in the first and second clusters; in the second one the CCAAT-box adjacent to the octamer overlaps with the TAAT-core site. As shown by gel retardation assay, Oct-1, Oct-2, and some unknown proteins from myeloma cell line NS/0 interact with the TAAT-core sites of these clusters. The results suggest autoregulation of Oct-1 gene expression that may also be controlled by other POU proteins, homeodomain proteins and CCAAT trans-action factors. |
