| First Author | Samoilova EB | Year | 1998 |
| Journal | Int Immunol | Volume | 10 |
| Issue | 4 | Pages | 491-8 |
| PubMed ID | 9620605 | Mgi Jnum | J:47275 |
| Mgi Id | MGI:1203249 | Doi | 10.1093/intimm/10.4.491 |
| Citation | Samoilova EB, et al. (1998) CTLA-4 is required for the induction of high dose oral tolerance. Int Immunol 10(4):491-8 |
| abstractText | Mucosal and systemic administrations of high dose antigens induce long-lasting peripheral T cell tolerance. We and others have shown that high dose peripheral T cell tolerance is mediated by anergy or deletion and is preceded by T cell activation. Co-stimulatory molecules B7-1 (CD80)/B7-2 (CD86) and their counter-receptors CD28/CTLA-4 play pivotal roles in T cell activation and immune regulation. In the present study, we examined the roles of the B7 co-stimulation pathway in the generation of high dose peripheral T cell tolerance. We found that blocking B7:CD28/CTLA-4 interaction at the time of tolerance induction partially prevented T cell tolerance, whereas selective blockade of B7:CTLA-4 interaction completely abrogated peripheral T cell tolerance induced by either oral or i.p. antigens. These results suggest that CTLA-4-mediated feedback regulation plays a crucial role in the induction of high dose peripheral T cell tolerance. |
