| First Author | Cifuentes-Diaz C | Year | 1998 |
| Journal | Cell Adhes Commun | Volume | 5 |
| Issue | 2 | Pages | 161-76 |
| PubMed ID | 9638336 | Mgi Jnum | J:48097 |
| Mgi Id | MGI:1261744 | Doi | 10.3109/15419069809040289 |
| Citation | Cifuentes-Diaz C, et al. (1998) Distinct location and prevalence of alpha-, beta-catenins and gamma-catenin/plakoglobin in developing and denervated skeletal muscle. Cell Adhes Commun 5(2):161-76 |
| abstractText | We studied the distribution of alpha-catenin, beta-catenin and gamma-catenin/plakoglobin in developing, adult and denervated mouse skeletal muscle. During primary myogenesis, all three catenins present a subsarcolemmal distribution within primary myotubes. During secondary myo-genesis they accumulate at myotube-myotube contacts. In contrast to the other catenins, gamma-catenin is strongly expressed in the sarcoplasm. In adult muscle, all three catenins are localized on the presynaptic elements of the neuromuscular junction. In denervated muscles, alpha- and beta-catenins are upregulated like N- and M-cadherin, while the levels of gamma-catenin/plakoglobin remain unchanged. The developmental changes in localization and regulation of alpha- and beta-catenins in muscle compared to gamma- catenin/plakoglobin are suggestive of a privileged association of alpha-and beta-catenins with N- and M-cadherins, while gamma- catenin/plakoglobin appears to be expressed quite independently and must assume a different role during myogenesis. |
