| First Author | Höppener JW | Year | 1998 |
| Journal | Genomics | Volume | 50 |
| Issue | 2 | Pages | 251-9 |
| PubMed ID | 9653652 | Mgi Jnum | J:48337 |
| Mgi Id | MGI:1267187 | Doi | 10.1006/geno.1998.5307 |
| Citation | Hoppener JW, et al. (1998) A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Genomics 50(2):251-9 |
| abstractText | In the process of identification of the multiple endocrine neoplasia type 1 gene, which was recently published, we isolated a novel gene in the 11q13 region. This gene (named ZFPL1, for zinc-finger protein-like 1) is expressed strongly in the exocrine pancreas as a 1,4-kb polyadenylated RNA encoding a putative protein of 310 amino acids. A mouse EST contig predicts an equally sized murine protein with 91% amino acid sequence identity to the human protein. No significant homology with known proteins could be found through database screening. However, zinc-fingerlike domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation. This notion is supported by the presence of a putative bipartite nuclear localization signal. This paper presents the full-length cDNA sequence for this gene, its genomic structure and chromosomal orientation, and expression studies by Northern blot hybridization and RNA in, situ hybridization. (C) 1998 Academic Press. |
