| First Author | Yahata T | Year | 1998 |
| Journal | Immunol Lett | Volume | 61 |
| Issue | 2-3 | Pages | 127-33 |
| PubMed ID | 9657265 | Mgi Jnum | J:47922 |
| Mgi Id | MGI:1206236 | Doi | 10.1016/s0165-2478(98)00006-6 |
| Citation | Yahata T, et al. (1998) Accumulation of IL-12-activated antitumor effector cells into lymph nodes of tumor-bearing mice. Immunol Lett 61(2-3):127-33 |
| abstractText | Simultaneous administration of high dose of IL-12 into tumor-inoculated mice resulted in a marked reduction of tumor growth in parallel with the augmented generation of cytotoxic T-cells, natural killer (NK) cells and IFN-gamma-producing Th cells. We found that these IL-12-activated antitumor effector cells preferentially accumulated in peripheral lymph nodes concomitantly with lymphadenopathy. However, IL-12 rather induced disappearance of antitumor effector cells including CD4+ T, CD8+ T and NK cells from spleen in spite of inducing splenomegaly. Lymph node cells obtained from IL-12-treated B16F0-bearing mice showed a marked IFN-gamma production in response to not only IL-2, IL-12, anti CD3 mAb but also B16F0 melanoma cells. Moreover, they could lyse B16F0 melanoma cells in a long-term cytotoxicity assay. It was also confirmed that IL-12-activated IFN-gamma producing Th1 cells were accumulated in tumor local site. Thus, IL-12 appeared to have a capability of stimulating selective migration of antitumor cells into lymph nodes and tumor local sites. |
