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Publication : NCAM: a polymorphic microsatellite locus conserved across eutherian mammal species.

First Author  Moore SS Year  1998
Journal  Anim Genet Volume  29
Issue  1 Pages  33-6
PubMed ID  9682447 Mgi Jnum  J:48472
Mgi Id  MGI:1270038 Doi  10.1046/j.1365-2052.1998.00234.x
Citation  Moore SS, et al. (1998) NCAM: a polymorphic microsatellite locus conserved across eutherian mammal species. Anim Genet 29(1):33-6
abstractText  A dinucleotide microsatellite was found to be conserved at the 3' untranslated end of the neural cell adhesion molecule (NCAM) gene in cattle, rat and human. The high level of sequence conservation found in this gene allows the use of a single set of PCR primers to amplify sequence spanning the repeat in many species. Sequence analysis revealed the conservation of the dinucleotide repeat in all eutherian mammal species studied with variation in length as well as internal structure caused by base substitutions. Polymorphisms were seen across five mammalian orders, in rat, buffalo, sheep, cow, whale and dolphin, with polymorphisms predicted in pig and dugong based on the length of the uninterrupted dinucleotide repeat.
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