| First Author | Chang A | Year | 1998 |
| Journal | Eur J Pharmacol | Volume | 351 |
| Issue | 2 | Pages | 189-91 |
| PubMed ID | 9687002 | Mgi Jnum | J:49182 |
| Mgi Id | MGI:1276821 | Doi | 10.1016/s0014-2999(98)00366-5 |
| Citation | Chang A, et al. (1998) Methadone analgesia in morphine-insensitive CXBK mice. Eur J Pharmacol 351(2):189-91 |
| abstractText | Methadone, a potent opioid analgesic, has long been considered a mu-opioid, based upon the similarities between its actions and those of morphine. This classification is supported by the sensitivity of methadone analgesia to the highly mu-opioid receptor-selective antagonist beta-funaltrexamine. Yet, CXBK mice respond normally to methadone despite their insensitivity to systemic morphine, distinguishing between the receptor mechanisms of the two drugs. Beta-funal-trexamine antagonizes methadone analgesia in CXBK mice, implying that the opioid is still acting through a mu-opioid receptor. These results reveal distinct analgesic mechanisms for morphine and methadone and provide further support for multiple subtypes of mu-opioid receptors. |
