| First Author | Moqrich A | Year | 1998 |
| Journal | Genomics | Volume | 51 |
| Issue | 1 | Pages | 136-9 |
| PubMed ID | 9693043 | Mgi Jnum | J:49523 |
| Mgi Id | MGI:1277628 | Doi | 10.1006/geno.1998.5342 |
| Citation | Moqrich a, et al. (1998) Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. Genomics 51(1):136-9 |
| abstractText | Rat striatin, a recently discovered calmodulin-binding protein belonging to the WD repeat family, is expressed in neurons, mostly in the striatum and motor and olfactory systems. Striatin is localized in the somato-dendritic compartment of neurons, mainly in the spines. It may play a role in dendritic Ca2+ signaling. Here we report the cloning and sequencing of human striatin cDNA (HGMW-approved symbol STRN), the localization of the gene to chromosome 2p22-p21, and its preferential expression in brain. The human cDNA sequence is predicted to encode a 780-amino-acid protein possessing eight WD repeats. Striatin is highly conserved between rat and human with 96% identity and 98% similarity at the amino acid level. Since the Caenorabditis elegans genome also contains a closely related striatin coding sequence, the function of striatin is likely to be well conserved. Copyright 1998 Academic Press. |
