| First Author | Schindler C | Year | 1998 |
| Journal | Trends Cell Biol | Volume | 8 |
| Issue | 3 | Pages | 97-8 |
| PubMed ID | 9695817 | Mgi Jnum | J:46431 |
| Mgi Id | MGI:1197848 | Doi | 10.1016/s0962-8924(98)01233-1 |
| Citation | Schindler C (1998) STATs as activators of apoptosis. Trends Cell Biol 8(3):97-8 |
| abstractText | STATs are a family of transcription factors that are activated in a ligand-dependent manner and promote the rapid induction of genes. They achieve this by directly transducing signals from the receptor into the nucleus. Consistent with their co-evolution with the cytokine family of ligands, studies have determined that STATs play a pivotal role in mediating the biological response for this family of ligands. However, STATs appear to have a dark side as well and contribute to programmed cell death. Intriguingly, a recent study suggests that this might occur in a manner that is distinct from the standard STAT signalling paradigm. |
