| First Author | Cheng FC | Year | 1998 |
| Journal | Neurosci Lett | Volume | 252 |
| Issue | 2 | Pages | 87-90 |
| PubMed ID | 9756328 | Mgi Jnum | J:49728 |
| Mgi Id | MGI:1278060 | Doi | 10.1016/s0304-3940(98)00554-0 |
| Citation | Cheng FC, et al. (1998) Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. Neurosci Lett 252(2):87-90 |
| abstractText | To mimic chronic exposure to neurotoxins in inducing dopaminergic cell damage, multiple doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were injected in C57BL/6 mice. Effects of pre- and post-treatment with the glial cell line-derived neurotrophic factor (GDNF) by injections into the striatum were investigated. GDNF exerts protective and reverse effects on the dopaminergic damage, supporting the potential application of GDNF in prevention and treatment of Parkinson's disease. |
