| First Author | Chin L | Year | 1998 |
| Journal | Trends Biochem Sci | Volume | 23 |
| Issue | 8 | Pages | 291-6 |
| PubMed ID | 9757829 | Mgi Jnum | J:49292 |
| Mgi Id | MGI:1277081 | Doi | 10.1016/s0968-0004(98)01236-5 |
| Citation | Chin L, et al. (1998) The INK4a/ARF tumor suppressor: one gene--two products--two pathways. Trends Biochem Sci 23(8):291-6 |
| abstractText | Functional inactivation of the retinoblastoma (RB) and p53 pathways appears to be a rite of passage for all cancerous cells and results in disruption of cell-cycle regulation and deactivation of the apoptotic response that normally ensues. The INK4a/ARF locus sits at the nexus of these two growth-control pathways, by virtue of its ability to generate two distinct products: the p16INK4a protein, a cyclin-dependent kinase inhibitor that functions upstream of RB; and the p19ARF protein, which blocks MDM2 inhibition of p53 activity. This 'one gene--two products--two pathways' arrangement provides a basis for the prominence of INK4a/ARF in tumorigenesis. |
