| First Author | Junta CM | Year | 1998 |
| Journal | Mol Cell Biochem | Volume | 187 |
| Issue | 1-2 | Pages | 67-72 |
| PubMed ID | 9788744 | Mgi Jnum | J:50567 |
| Mgi Id | MGI:1306951 | Doi | 10.1023/a:1006807021251 |
| Citation | Junta CM, et al. (1998) Emergence of TCR alpha/beta V(D)J recombination and transcription during ontogeny of inbred mouse strains. Mol Cell Biochem 187(1-2):67-72 |
| abstractText | The maturation of T-cells depends on V(D)J recombination at the TCR alpha/beta and gamma/delta loci that occurs in the thymus during fetal development. Due to the essential role of the TCR beta in thymocyte differentiation, it is important to define with precision the temporal emergence of the TCR beta rearrangement and its expression in normal non-manipulated mouse strains. We studied the onset of the V(D)J recombination and transcription of the TCR V alpha 3 and V beta 11 genes during ontogeny in Balb-c, C57B1/6 and CBA inbred mouse strains. Our data show differences in the emergence of recombination in both TCR alpha and beta loci among strains. The transcriptions of these loci followed respective recombinations and we detected an early germline transcript before TCR beta locus recombination in the CBA strain. |
