| First Author | McBride JL | Year | 1998 |
| Journal | Mech Dev | Volume | 77 |
| Issue | 2 | Pages | 201-4 |
| PubMed ID | 9831653 | Mgi Jnum | J:51431 |
| Mgi Id | MGI:1316612 | Doi | 10.1016/s0925-4773(98)00142-7 |
| Citation | McBride JL, et al. (1998) Ephrin-A1 is expressed at sites of vascular development in the mouse. Mech Dev 77(2):201-4 |
| abstractText | B61 (ephrin-A1), a ligand for eph receptor-protein tyrosine kinases, possesses angiogenic and endothelial cell chemoattractant activity. We report the expression profile of ephrin-A1 during mouse embryogenesis (7.25 to 10.5 days post-coitum (dpc)). Ephrin-A1 expression was first detected in the caudal end of the primitive streak and the developing allantois. At mid head fold stage, ephrin-A1 transcripts were observed in the anterior pharyngeal endoderm that underlies the site of the future heart. In 8.0 to 8.5 dpc embryos, ephrin-A1 was expressed in presumptive endocardial cells, the dorsal aorta, and the primary head veins. In 9.5 to 10.5 dpc embryos, ephrin-A1 RNA was detected in intersomitic vessels and the limb bud vasculature. Each site of ephrin-A1 expression corresponded to regions of vasculogenesis and/or angiogenesis. Copyright 1998 Elsevier Science Ireland Ltd. All Rights Reserved |
