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Publication : The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes.

First Author  Bauer UM Year  1998
Journal  FEBS Lett Volume  439
Issue  3 Pages  208-14
PubMed ID  9845324 Mgi Jnum  J:51271
Mgi Id  MGI:1314957 Doi  10.1016/s0014-5793(98)01327-1
Citation  Bauer UM, et al. (1998) The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes. FEBS Lett 439(3):208-14
abstractText  We have studied the expression of the nuclear orphan receptor GCNF (germ cell nuclear factor) on the mRNA and protein level in pubertal and adult mouse testes. We show by Northern and Western blot analyses and by in situ hybridization that GCNF is expressed in spermatocytes and round spermatids of adult mouse testis suggesting that GCNF may be a transcriptional regulator of spermatogenesis. Since the GCNF protein is accumulated in the XY body of late pachytene spermatocytes, it may be involved in transcriptional inactivation of sex chromosomes.
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