| First Author | Nachman MW | Year | 1998 |
| Journal | Mol Biol Evol | Volume | 15 |
| Issue | 12 | Pages | 1744-50 |
| PubMed ID | 9866208 | Mgi Jnum | J:52180 |
| Mgi Id | MGI:1328534 | Doi | 10.1093/oxfordjournals.molbev.a025900 |
| Citation | Nachman MW (1998) Y chromosome variation of mice and men. Mol Biol Evol 15(12):1744-50 |
| abstractText | DNA sequences from the nonrecombining portion of the Y chromosome were compared with autosomal and X-linked sequences from mice and humans to test the neutral prediction that ratios of polymorphism to divergence are the same for different genes. Intraspecific variation within Mus domesticus was compared with divergence between M. domesticus and Mus caroli for Sry, a region 5' to Sry, and four X-linked genes, Hprt, Plp, Amg, and Glra2. None of these comparisons revealed significantly reduced variation on the Y chromosome. Intraspecific variation within humans was compared with divergence between humans and chimpanzees for three Y-linked loci (Zfy, the YAP region, and the Sry region), seven X-linked loci (Il2rg, Plp, Hprt, Gk, Ids, Pdhal, and Dmd), and the beta-globin locus on chromosome 11. In these comparisons, the observed level of variation on the human Y chromosome was slightly lower than expected, but was significantly lower in only one case (Sry region vs. Dmd). These results suggest that the levels of variability on the Y chromosome in mice and humans are close to expected values given the effective population size and mutation rates for these loci. There is at most only a modest reduction in variability that may be attributed to natural selection (either genetic hitchhiking or background selection). |
