| First Author | Broccardo C | Year | 1998 |
| Journal | Eur J Hum Genet | Volume | 6 |
| Issue | 6 | Pages | 638-41 |
| PubMed ID | 9887385 | Mgi Jnum | J:52462 |
| Mgi Id | MGI:1329521 | Doi | 10.1038/sj.ejhg.5200233 |
| Citation | Broccardo C, et al. (1998) Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP). Eur J Hum Genet 6(6):638-41 |
| abstractText | ALDR is one of the four genes encoding an ATP Binding Cassette (ABC) hemi-transporter of the peroxisomal membrane so far identified in mammalian cells, The best known of these is X-ALD, whose dysfunction has been causally associated with X-linked adrenoleukodystrophy. ALDR and X-ALD protein product are closely related and we show here that this striking conservation is maintained at the genomic level, Although extending to a larger genomic region, the organisation of the mouse ALDR gene mirrors exactly that of X-ALD. This supports further the hypothesis that among the four known peroxisomal ABC hemi- transporters ALDRP is the most likely candidate as a modifier contributing to the phenotypic variability of X- linked adrenoleukodystrophy. |
