| First Author | Jones EP | Year | 1999 |
| Journal | Immunogenetics | Volume | 49 |
| Issue | 3 | Pages | 183-95 |
| PubMed ID | 9914332 | Mgi Jnum | J:53265 |
| Mgi Id | MGI:1331584 | Doi | 10.1007/s002510050479 |
| Citation | Jones EP, et al. (1999) Mhc class I and non-class I gene organization in the proximal H2-M region of the mouse. Immunogenetics 49(3):183-95 |
| abstractText | A bacterial artificial chromosome (BAC) contig was constructed across the proximal part of the H2-M region from the major histocompatibility complex (Mhc) of mouse strain 129 (H2(bc)). The contig is composed of 28 clones that span approximately 1 megabasepair (Mb), from H2-T1 to Mog, and contains three H2-T genes and 18 H2-M genes. We report the fine mapping of the H2-M class I gene cluster, which includes the previously reported M4-M6, the M1 family, the M10 family, and four additional class I genes. All but two of the H2-M class I genes are conserved among haplotypes H2(k), H2(b), and H2(bc), and only two genes are found in polymorphic HindIII fragments. Six evolutionarily conserved non-class I genes were mapped to a 180 kilobase interval in the distal part of the class I region in mouse, and their order Znf173-Rfb30-Tctex5-Tctex6-Tctex4- Mog was found conserved between human and mouse. In this Znf173-Mog interval, three mouse class I genes, M6, M4, and M5, which are conserved among haplotypes, occupy the same map position as the human HLA-A class I cluster, which varies among haplotypes and is diverged in sequence from the mouse genes. These results further support the view that class I gene diverge and evolve independently between species. |
