| First Author | Caffrey JJ | Year | 1999 |
| Journal | FEBS Lett | Volume | 442 |
| Issue | 1 | Pages | 99-104 |
| PubMed ID | 9923613 | Mgi Jnum | J:52074 |
| Mgi Id | MGI:1327776 | Doi | 10.1016/s0014-5793(98)01636-6 |
| Citation | Caffrey JJ, et al. (1999) The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. FEBS Lett 442(1):99-104 |
| abstractText | We have derived the full-length sequences of the human and rat forms of the multiple inositol polyphosphate phosphatase (MIPP); their structural and functional comparison with a chick histidine acid phosphatase (HiPER1) has revealed new information: (1) MIPP is approximately 50% identical to HiPER1, but the ER-targeting domains are divergent; (2) MIPP appears to share the catalytic requirement of histidine acid phosphatases, namely, a C-terminal His residue remote from the RHGxRxP catalytic motif; (3) rat MIPP mRNA is up-regulated during chondrocyte hypertrophy. The latter observation provides a context for proposing that MIPP may aid bone mineralization and salvage the inositol moiety prior to apoptosis. |
