| First Author | Moscatello KM | Year | 1999 |
| Journal | Cell Immunol | Volume | 191 |
| Issue | 2 | Pages | 124-30 |
| PubMed ID | 9973534 | Mgi Jnum | J:53134 |
| Mgi Id | MGI:1331319 | Doi | 10.1006/cimm.1998.1420 |
| Citation | Moscatello KM, et al. (1999) Effects of in utero alcohol exposure on B cell development in neonatal spleen and bone marrow. Cell Immunol 191(2):124-30 |
| abstractText | The effects of in utero alcohol exposure on neonatal lymphopoiesis were examined in a murine model of fetal alcohol syndrome. At birth, both immature and mature B cells were decreased in the spleens of neonatal animals and these subpopulations of B cells did not recover to normal levels until 3-4 weeks of life. Pre-B cells and total B cells were decreased as well in the bone marrow of ethanol-exposed animals. By 3-4 weeks of life, the number of B cells in the bone marrow recovered to normal levels, but the pre-B cells remained below normal levels through 5 weeks of age. Furthermore, a recently described early B cell progenitor was reduced in frequency in ethanol-exposed neonates. Together, these data suggest that in utero exposure to ethanol can result in abnormalities in B cell development that may initiate at an early stage of B cell development. Copyright 1999 Academic Press. |
