| First Author | van Endert PM | Year | 1999 |
| Journal | Curr Opin Immunol | Volume | 11 |
| Issue | 1 | Pages | 82-8 |
| PubMed ID | 10047538 | Mgi Jnum | J:53144 |
| Mgi Id | MGI:1331329 | Doi | 10.1016/s0952-7915(99)80015-6 |
| Citation | van Endert PM (1999) Genes regulating MHC class I processing of antigen. Curr Opin Immunol 11(1):82-8 |
| abstractText | The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing. |
