| First Author | Kamp PB | Year | 1999 |
| Journal | Gene | Volume | 229 |
| Issue | 1-2 | Pages | 137-44 |
| PubMed ID | 10095113 | Mgi Jnum | J:53952 |
| Mgi Id | MGI:1333677 | Doi | 10.1016/s0378-1119(99)00036-0 |
| Citation | Kamp PB, et al. (1999) Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. Gene 229(1-2):137-44 |
| abstractText | The genomic organization of the heparin cofactor II (HCII) gene from rat and mouse was investigated and compared with their human counterpart. The genes share a common core structure consisting of five exons interrupted by four introns, but the mouse and rat gene reveal individual additional features. A unique differentially spliced exon is present in the 5'-untranslated region of the rat gene, which most probably has arisen de novo by point mutations in intronic sequences of the ancestor gene. In the mouse HCII gene, a novel intron/exon boundary has been created due to the presence of an additional DNA segment, which simultaneously provides a 3'-splice site and a polypyrimidine stretch leading to an alternatively used exon of increased size. Our data suggest that, in contrast to most other mammalian genes, the exon/intron pattern of the gene coding for HCII is in dynamic evolution. |
