| First Author | Chodosh LA | Year | 1999 |
| Journal | Cancer Res | Volume | 59 |
| Issue | 7 Suppl | Pages | 1765-1771s; discussion 1771s-1772s |
| PubMed ID | 10197594 | Mgi Jnum | J:44157 |
| Mgi Id | MGI:1346981 | Citation | Chodosh LA, et al. (1999) Mammary gland development, reproductive history, and breast cancer risk. Cancer Res 59(7 Suppl):1765-1771s; discussion 1771s-1 |
| abstractText | The observation that normal pathways of differentiation and development are invariably altered during the process of carcinogenesis implies an intrinsic relationship between these processes. This relationship is particularly evident in the breast, as exemplified by the existence of endocrine risk factors for breast cancer that are related to the timing of normal developmental events. Understanding the mechanisms by which normal developmental events alter breast cancer risk is a central focus of our laboratory. Herein, we describe three approaches being taken in our laboratory toward defining the molecular basis of this relationship. These include: determining the roles played by the tumor suppressor genes, BRCA1 and BRCA2, in the normal differentiation and development of the breast; studying the function of three novel protein kinases identified in our laboratory in mammary epithelial development; and defining the molecular and cellular changes that occur in the breast as a result of reproductive events known to influence breast cancer risk. |
