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Publication : The novel sarcomeric protein telethonin exhibits developmental and functional regulation.

First Author  Mason P Year  1999
Journal  Biochem Biophys Res Commun Volume  257
Issue  3 Pages  699-703
PubMed ID  10208846 Mgi Jnum  J:54680
Mgi Id  MGI:1335699 Doi  10.1006/bbrc.1999.0531
Citation  Mason P, et al. (1999) The novel sarcomeric protein telethonin exhibits developmental and functional regulation. Biochem Biophys Res Commun 257(3):699-703
abstractText  We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly. Copyright 1999 Academic Press.
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