| First Author | Grewal A | Year | 1999 |
| Journal | Horm Metab Res | Volume | 31 |
| Issue | 2-3 | Pages | 155-60 |
| PubMed ID | 10226797 | Mgi Jnum | J:54673 |
| Mgi Id | MGI:1335692 | Doi | 10.1055/s-2007-978714 |
| Citation | Grewal A, et al. (1999) Expression of IGF system genes during T-antigen driven pituitary tumorigenesis. Horm Metab Res 31(2-3):155-60 |
| abstractText | Expression of IGF-I, IGF-II, the Type-I IGF receptor and six IGF binding proteins were examined in three different T-ag-driven mouse tumors. Unlike the widespread expression of IGF-II in pancreatic beta-cell tumors, IGF-II was not widely expressed in the two different pituitary tumors examined indicating that a mechanism independent of focal IGF-II expression can also drive T-antigen tumorigenesis. In addition, multiple IGF binding proteins were expressed in all three tumor types. This expression, however, was generally heterogeneous with no specific changes to indicate a required role for any IGF binding protein in T-antigen tumorigenesis. |
